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What is Ultracet?

Ultracet is a prescription drug available in both brand and generic forms. It consists of acetaminophen and tramadol that help treat moderate to severe pain. Ultracet is available in various forms and strengths, and your medical healthcare provider may assign an individual dosage schedule for you.

Tramadol belongs to the opioid analgesics category of drugs and functions in the brain to change the feeling and response of the body towards pain. At the same time, acetaminophen relieves fever and reduces the pain in your body.

Ultracet may expose you to the risk of opioid misuse, addiction, or overuse leading you to overdose or death. It is still a question whether Ultracet is safe and effective in children below 16 years of age or not.

Important Information

Ultracet comes with the risk of abuse, misuse, or addiction. Addiction occurs primarily when someone overuses or misuses the drug.

Ultracet may cause life-threatening, severe, or fatal respiratory depression. With time, respiratory depression can lead to respiratory arrest and death. Your medical healthcare provider may help manage such a medical condition by close observation, use of opioid antagonists, and supportive measures, depending upon your clinical status.

Ultracet may cause neonatal opioid withdrawal syndrome if you take this drug during pregnancy. The withdrawal symptoms in a newborn baby can be hazardous and may lead the infant to death.

What to know before taking Ultracet?

Before taking Ultracet, ensure to share your medical history so that your medical healthcare provider documents your previous medical conditions. Do not take Ultracet if you are allergic to it or any component it contains.

Components of Ultracet may cause such a condition that affects the QT prolongation (heart rhythm) that contains some rare but severe fast or irregular heartbeat and other symptoms such as fainting and dizziness that need medical attention immediately.

Use this medicine only when you urgently need it during pregnancy but only with prior medical consultation. It may cause a medical issue to your unborn baby. This medication can easily pass through the breastmilk and harm your nursing baby producing undesirable effects such as difficulty feeding, unusual sleepiness, or trouble breathing.

How to take Ultracet?

It would be best if you took Ultracet tablets for the management of acute pain. The pain must be severe enough to require an opioid analgesic and should be administered only when other alternative treatments are inadequate.

Ultracet tablets are for short-term use only, and you must not take them for more than five days. Even at regular doses, it comes with the risks of abuse, overuse, or addiction similar to other opioids.

Do not exceed the amount of the medicine for fast pain relief. It will not relieve the pain faster; instead, it increases the risk of side effects. Your medical healthcare provider may offer you the lowest effective dose for the shortest duration, keeping future dangers in mind.

Ultracet dosage

Usual adult dosage for pain:

  • The typical initial dose is two tablets orally within every 4 to 6 hours as needed
  • The maximum quantity of a day should not exceed eight tablets.
  • The maximum duration of the treatment should not exceed five days.

There may be a modification in patients with renal impairment, and their dosage should not exceed two tablets within every 12 hours.


If you have an overdose with severe symptoms such as trouble breathing or passing out, call 911. Your medical healthcare provider may ask you to keep naloxone, an opioid overdose reversal drug. Your attendant or caregiver should know where you saved the naloxone and give it to you when you stop breathing or don’t wake up.

Overdose symptoms of Ultracet may include the following:

  • Slow or shallow breathing;
  • Vomiting and nausea with loss of appetite;
  • Slow or irregular heartbeat;
  • Sweating with extreme tiredness;
  • Stomach or abdominal cramps;
  • Seizure (or convulsions);
  • Yellowing of skin or eyes;
  • Dark urine; or
  • Coma

If you or the person having an overdose is awake, call a poison control center immediately. US residents may dial their poison control helpline at 1-800-222-1222. At the same time, Canadian residents should call their particular provincial poison control center.

What to avoid while using Ultracet?

Dangerous side effects or death can occur if you keep drinking alcohol while getting treatment with Ultracet.

Ultracet can cause severe dizziness or drowsiness, resulting in accidental falls or injuries. So, avoid driving any vehicle or performing any task that requires alertness until you know how this medicine will affect your consciousness.

Ask your medical healthcare provider before taking any other product that may contain acetaminophen (or APAP). The use of certain medications at the same time can cause a fatal overdose.

Ultracet side effects

Here is a list of possible common and rare side effects of Ultracet, including: 

  • Flushing, itching, and burning of the skin;
  • Cough with chest pain or tightness;
  • Trouble breathing and difficulty with swallowing;
  • Dizziness, unusual weakness or tiredness;
  • Hives, rash, or itching skin;
  • Vomiting, seizure (or convulsions)

Some of the severe or less common side effects of Ultracet that may need you to consult your medical healthcare provider or seek medical help:

  • Belching, anxiety, bloating (feeling of fullness);
  • Dry mouth, constipation, feeling of warmth;
  • Unusual sense of well-being;
  • Excess gas in stomach or bowels;
  • Heartburn, indigestion, loose stools;
  • Increase in bowel movements, sweating;
  • Loss of energy, muscle weakness, or pain;
  • Painful urination, soft stools, stomach discomfort;
  • Unusual drowsiness, weight loss;
  • Redness of the upper chest, arms, face, and neck

Some of the rare and severe side effects of Ultracet may include:

  • Abnormal thinking, loss of memory, crying;
  • Cold sweats, changes in vision;
  • Feeling unusually cold, harsh, or continuing headache;
  • Severe stomach pain, shivering;
  • Shakiness and unstable walk;
  • Vomiting of blood, involuntary muscle contractions;
  • Migraine headache, rapidly changing moods

If you have more such side effects, consult your medical healthcare provider, or you may report it to the FDA at 1-800-FDA-1088.

What drugs can interact with Ultracet?

Some products that may interact with Ultracet and change the working of this drug in your body may include particular pain medications and mixed opioid agonist-antagonists such as nalbuphine, butorphanol, pentazocine, and naltrexone.

If you have been taking MAO inhibitors for the last 14 days, it may also interact with Ultracet. So, avoid taking any of the following MAO inhibitors:

  • Methylene blue,
  • Isocarboxazid,
  • Linezolid,
  • Procarbazine,
  • Moclobemide,
  • Phenelzine,
  • Tranylcypromine,
  • Safinamide,
  • Selegiline

Drug interaction may also cause serotonin syndrome or serotonin toxicity. You should avoid taking the following drugs:

  • St. John’s wort;
  • Specific antidepressants;
  • SSRIs such as paroxetine or fluoxetine; and
  • SNRIs such as venlafaxine or duloxetine